Methylphenidate Alternatives Compared
Methylphenidate | Rexulti | Bupropion |
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Methylphenidate | Rexulti (brexpiprazole) | Bupropion |
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Prescription only
Methylphenidate improves symptoms of ADHD but carries with it a risk of dependence and side effects such as insomnia are common. To avoid insomnia the last dose should be administered before 6 pm... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions |
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More about Methylphenidate | More about Rexulti (brexpiprazole) | More about Bupropion | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Methylphenidate has an average rating of 7.2 out of 10 from a total of 1063 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 17% reported a negative effect. |
Rexulti has an average rating of 6.4 out of 10 from a total of 453 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 27% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2850 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: methylphenidate side effects in more detail. |
See also: Rexulti side effects in more detail. |
See also: bupropion side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all methylphenidate prices |
View all Rexulti prices |
View all bupropion prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Daytrana, Jornay PM, Metadate CD, Methylin, Methylin ER, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA View more |
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
4 hours |
91 hours |
30 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 198 drugs are known to interact with methylphenidate:
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A total of 580 drugs are known to interact with Rexulti:
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A total of 497 drugs are known to interact with bupropion:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
December 05, 1955 |
July 10, 2015 |
December 30, 1985 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.