Modafinil Alternatives Compared
Modafinil | Rexulti | Bupropion |
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Modafinil | Rexulti (brexpiprazole) | Bupropion |
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Prescription only
Prescribed for Chronic Fatigue Syndrome, ADHD, Depression, Fatigue, Obstructive Sleep Apnea/Hypopnea Syndrome, Shift Work Sleep Disorder, Narcolepsy, Idiopathic Hypersomnia. modafinil may also be... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions |
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More about Modafinil | More about Rexulti (brexpiprazole) | More about Bupropion | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Modafinil has an average rating of 7.3 out of 10 from a total of 513 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
Rexulti has an average rating of 6.4 out of 10 from a total of 453 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 27% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2850 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: modafinil side effects in more detail. |
See also: Rexulti side effects in more detail. |
See also: bupropion side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all modafinil prices |
View all Rexulti prices |
View all bupropion prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Provigil |
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
15 hours |
91 hours |
30 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 499 drugs are known to interact with modafinil:
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A total of 580 drugs are known to interact with Rexulti:
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A total of 497 drugs are known to interact with bupropion:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
December 24, 1998 |
July 10, 2015 |
December 30, 1985 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.