What's the difference between Xywav and Xyrem?
Xywav is a low-sodium alternative to Xyrem, approved in 2020 after concerns about the high sodium content of Xyrem potentially contributing to heart disease.
- Xywav contains 92% less sodium than Xyrem and may be more suitable for people on a low salt diet or those who are at risk of high blood pressure. Xyrem carries warnings about its high sodium content.
- Xywav only contains 131mg sodium in a daily 9g dose compared with Xyrem which contains 1640mg of sodium per 9g dose. The American Heart Association recommends no more than 2,300 mg of sodium a day, preferably less than 1,500 mg per day.
- Xywav contains the same amount of oxybate as Xyrem, but as a mixture of calcium, magnesium, potassium, and sodium oxybate salts, instead of solely sodium oxybate salts, which make up Xyrem.
- Doctors can initiate Xywav at the same dosage as Xyrem.
References
- Xywav (calcium, magnesium, potassium, and sodium oxybates) Xywav.com https://www.xywav.com/
- Xywav (calcium, magnesium, potassium, and sodium oxybates) [Product information] Updated 03/2022. Jazz Pharmaceuticals, Inc. https://www.drugs.com/pro/xywav.html#s-34090-1
Read next
Related medical questions
- How does Xyrem work for narcolepsy?
- Is Xyrem a controlled substance / narcotic drug of abuse?
- How much sodium is in Xyrem?
- Can any doctor prescribe Xyrem?
- Can you take Xyrem while pregnant?
- Can you have narcolepsy and insomnia?
- What are the early signs of narcolepsy?
- What is the difference between narcolepsy and idiopathic hypersomnia?
- How do you test for narcolepsy?
- What is the treatment for narcolepsy?
- Modafinil (Provigil) vs Adderall: What's the difference?
- What exactly is Captagon and why was it banned?
- Focalin vs Adderall: What's the difference?
- How long does Adderall withdrawal last?
- Modafinil: Smart Drug For Decision Fatigue Or Workaholic Crutch?
- Ritalin vs Vyvanse - What's the difference between them?
- What are the brands of methylphenidate?
- Adderall for Study: Does it Really Make You Smarter?
- What is metilfenidato used for?
- Is Adzenys XR-ODT the same as Adderall XR?
- Is Sunosi (solriamfetol) a controlled substance?
- How does Wakix work for narcolepsy?
- Is Wakix a controlled substance?
Drug information
Related support groups
- Xyrem (9 questions, 75 members)
- Xywav (2 questions, 5 members)
- Narcolepsy (79 questions, 397 members)
- Cataplexy (8 questions, 50 members)
- Idiopathic Hypersomnia (4 questions, 7 members)